We are currently conducting genomic and ...

Anaerobic bacteria are part of normal human endogenous flora. The number of anaerobic bacteria progressively increased in the gastrointestinal tract to the colon where they are one thousand times greater than the aerobic bacteria. Some of these anaerobic bacteria are part of the infectious process, often based on an opportunistic event, or after the anatomical and physiological disturbances infectious sites. Anaerobic bacteria are pathogenic bacteria is to themselves, but can be increased at the expense of the host dependent factors (immunodeficiency), and bacterial protection. Bacteroides and Clostridium are the two main anaerobic bacteria can be found in the flora of colic. Among the pathogens Clostridium,

Clostridium difficile is responsible for 15 to 25% of all strattera cases of antibiotic-associated diarrhea and pseudomembranous colitis for most. This is the main bacterial enteropathogen isolated in nosocomial diarrhea in adults. Since 2003, highly pathogenic strains of the microorganism appeared and the speed and severity of infections

C difficile has increased dramatically. Many virulence factors seem to be involved in the

C difficile infection, but the production of two toxins (TcdA and TcdB) plays an important role in the pathogenicity of this bacterium. The main research activities of the laboratory is aimed at the mechanisms involved in the initiation of transcription of genes encoding C difficile toxin in the regulation of their expression, both during the growth phase (phase transition) as well as in response to various environmental signals (sources of carbon, sulfur-containing amino acids) . Toxin secretion were also studied. We also identify factors involved in colonization of the gastrointestinal tract from

C difficile (sporulation, adhesion, adaptation, multiplication) using

in-vitro and in vivo comparative analysis of genes, C. difficile

, when recovered from the infectious context (sterile mouse model). We are currently conducting genomic and transcriptomic comparative analysis of highly pathogenic strains of the microorganism. We expect to determine the factors responsible for the emergence and hypervirulence epidemic strains, as in the U.S. and Europe. .